Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (22): 2039-2049.doi: 10.3969/j.issn.1673-5374.2013.22.003

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Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage

Jixiang Ren1, Xiangyu Zhou2, Jian Wang1, Jianjun Zhao1, Pengguo Zhang3   

  1. 1 Department of Encephalopathy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China
    2 Grade 2010 Clinical Medicine Major, School of Clinical Medicine, Yanbian University, Yanji 133002, Jilin Province, China
    3 Department of Imaging, School of Second Clinical Medicine, Jilin University, Changchun 130041, Jilin Province, China
  • Received:2013-04-12 Revised:2013-07-08 Online:2013-08-05 Published:2013-08-05
  • Contact: Jianjun Zhao, Master, Professor, Doctoral supervisor, Department of Encephalopathy, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China, zhaojianjun8777@163.com. Pengguo Zhang, M.D., Associate professor, Master’s supervisor, Department of Imaging, School of Second Clinical Medicine, Jilin University, Changchun 130041, Jilin Province, China, Zhangyangren@126.com.
  • About author:Jixiang Ren, M.D., Attending physician. Jixiang Ren and Xiangyu Zhou contributed equally to this article.
  • Supported by:

    国家中药研究基地（中风病）建设项目；吉林省自然科学基金项目（201015211）。

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Abstract:

This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood. Rat models were intragastrically administered 5, 10, 20 g/kg Poxue Huayu and Tianjing Busui Decoction, supplemented with Hirudo, raw rhubarb, raw Pollen Typhae, gadfly, Fructrs Trichosanthis, Radix Notoginseng, Rhizoma Acori Talarinowii, and glue of tortoise plastron, once a day, for 14 consecutive days. Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage, and intracerebral hematoma volume markedly reduced after treat-ment. Immunohistochemical staining revealed that brain-derived neurotrophic factor, tyrosine ki-nase B and vascular endothelial growth factor expression noticeably increased around the sur-rounding hematoma. Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma. Neurologic impairment obviously reduced. These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor.

Key words: neural regeneration, traditional Chinese medicine, cerebral hemorrhage, brain-derived neurotrophic factor, tyrosine kinase B, vascular endothelial growth factor, Poxue Huayu and Tianjing Busui, grants-supported paper, neuroregeneration