Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (8): 702-707.doi: 10.3969/j.issn.1673-5374.2013.08.004

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Role of calbindin-D28K in estrogen treatment for Parkinson’s disease

Chunhua Wang1, 2, 3, Chao Jiang1, Honghua Yuan1, Chenghua Xiao2, Dianshuai Gao1, 2   

  1. 1 Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
    2 Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China
    3 Department of Neurology, Funing County People’s Hospital, Yancheng 224400, Jiangsu Province, China
  • Received:2012-05-22 Revised:2012-09-15 Online:2013-03-15 Published:2013-03-15
  • Contact: Dianshuai Gao, M.D., Professor, Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China; Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China, gds@xzmc.edu.cn.
  • About author:Chunhua Wang★, Master.

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Abstract:

Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson’s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson’s disease.

Key words: neural regeneration, neurodegenerative diseases, estrogen, calbindin-D28K, Parkinson’s disease, dopaminergic neuron, tyrosine hydroxylase, photographs-containing paper, neuroregeneration