Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (8): 714-722.doi: 10.3969/j.issn.1673-5374.2013.08.006

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Chronic exercise training versus acute endurance exercise in reducing neurotoxicity in rats exposed to lead acetate

Mohammad Shahandeh1, Valiollah Dabidi Roshan2, Somayeh Hosseinzadeh3, Soleiman Mahjoub4, Vaginak Sarkisian1   

  1. 1 L.Orbeli Inst. of Physiology, NAS of Armenia, Yerevan, Republic of Armenia
    2 College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran, Babolsar, Iran
    3 Babol University of Medical Sciences, Babol, Iran
    4 Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  • Received:2012-10-08 Revised:2013-01-05 Online:2013-03-15 Published:2013-03-15
  • Contact: Somayeh Hosseinzadeh, M.Sc, Babol University of Medical Sciences, Babol, Iran, hoseinzadeh87@ yahoo.com.
  • About author:Mohammad Shahandeh☆, Studying for doctorate.

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Abstract:

After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15–22 m/min, 25–64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus (P = 0.04) and plasma level of total antioxidant capacity of rats exposed to lead acetate (P < 0.001), and significantly decreased plasma level of malondialdehyde (P < 0.001). Acute exercise only decreased the hippocampal malondialdehyde level (P = 0.09) and increased brain-derived neurotrophic factor level in the hippocampus (P = 0.66). Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly (P = 0.99). These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.

Key words: neural regeneration, neurorehabilitation, long-term exercise training, endurance exercise, treadmill, lead poisoning, neurotoxicity, oxidative stress, hippocampus, brain-derived neurotrophic factor, neuroregeneration