Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (3): 421-422.doi: 10.4103/1673-5374.228721.

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Microcebus murinus: a novel promising non-human primate model of spinal cord injury

Gaëtan Poulen1, 2, Florence Evelyne Perrin1   

  1. 1 University of Montpellier, Institut National de la Santé et de la Recherche Médicale Unit 1198, Montpellier, France
    2 Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France
  • Received:2018-02-23 Online:2018-03-15 Published:2018-03-15
  • Contact: Florence Evelyne Perrin, Ph.D.,florence.perrin@inserm.fr
  • Supported by:

    This work was supported by the patient organizations “Verticale” and “Demain Debout Aquitaine”.

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Abstract:

The number of people affected by spinal cord injuries (SCI) ranges from 2.5 to 4 million worldwide. Traumatic SCI induces a primary injury due to initial mechanical impact that causes focal cellular and blood-spinal cord barrier damages. Subsequently, secondary injuries resulting from infiltration of peripheral monocytes, ischemia, edema,inflammation, glial scar and cystic cavities formation as well as excitotoxicity trigger cellular demise and prevent spontaneous axonal regrowth. Secondary damages, including aggregation of extracellular matrix protein at the lesion epicenter, thus greatly amplify impairments induced by the initial mechanical damage.