Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (2): 325-326.doi: 10.4103/1673-5374.346478

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Schwann cell extracellular vesicles: judging a book by its cover

Steven L. Gonias, Wendy M. Campana*   

  1. Department of Pathology, University of California, San Diego, CA, USA (Gonias SL)
    Department of Anesthesiology, Program in Neurosciences, University of California; The Veterans Administration San Diego Healthcare System, San Diego, CA, USA (Campana WM)
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Wendy M. Campana, PhD, wcampana@health.ucsd.edu.
  • Supported by:
    This work was supported by 1I01 RX003363 from the Veterans Administration (to WMC). 

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Abstract: Schwann cells (SCs) are essential in the development of the peripheral nervous system (PNS), in PNS injury, and the aging PNS. SCs comprise greater than 90% of the nucleated cells in peripheral nerves (Campana, 2007). Myelinating SCs insulate large-diameter axons, forming a 1:1 relationship and promoting saltatory conduction of axonal action potentials. Non-myelinating SCs ensheathe clusters of smaller diameter axons in Remak bundles. Both types of SCs provide essential metabolic and trophic support to axons, which is essential for maintaining axon integrity in healthy peripheral nerves.