Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (8): 1696-1701.doi: 10.4103/1673-5374.389364

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The role of snapin in regulation of brain homeostasis

Jiawen Li1, 2, #, Xinqi Huang2, #, Yumei An2, #, Xueshi Chen2, Yiyang Chen2, Mingyuan Xu2, Haiyan Shan3, *, Mingyang Zhang1, 2, *   

  1. 1Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science), Shanghai, China; 2Institute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu Province, China; 3Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Mingyang Zhang, MD, PhD, mingyangzhang@suda.edu.cn; Haiyan Shan, MD, PhD, ghostqth@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82071382 (to MZ), 81601306 (to HS); the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (to MZ); Jiangsu 333 High Level Talent Training Project (2022) (to HS); the Jiangsu Maternal and Child Health Research Key Project (F202013) (to HS); Jiangsu Talent Youth Medical Program, No. QNRC2016245 (to HS); Shanghai Key Lab of Forensic Medicine, No. KF2102 (to MZ); Suzhou Science and Technology Development Project, No. SYS2020089 (to MZ); the Fifth Batch of Gusu District Health Talent Training Project, No. GSWS2019060 (to HS).

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Abstract: Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

Key words: brain homeostasis, diabetes, neurological diseases, snapin, traumatic brain injury, vesicle fusion