Abstract: Brain lesions, such as those caused by stroke or traumatic brain injury (TBI), frequently result in persistent motor and cognitive impairments that significantly affect the individual patient’s quality of life. Despite differences in the mechanisms of injury, both conditions share a high prevalence of motor and cognitive impairments. These deficits show only limited natural recovery. Therefore, the impairments following brain injury mandate better treatment and represent critically important targets for novel interventional strategies in neurorehabilitation. By focusing on improving recovery and promoting functional independence, neurorehabilitation plays a crucial role in helping individuals regain the ability to perform daily life activities, addressing the growing global burden of neurological disorders. Non-invasive brain stimulation has emerged as a promising approach to neurorehabilitation, with its capacity to modulate activity in targeted brain regions. Techniques such as transcranial direct current stimulation and transcranial magnetic stimulation (TMS) are among the most extensively studied, recognized for their potential to influence cortical activity and induce changes across motor, sensory, and cognitive networks. While these methods are considered safe compared to invasive alternatives, they have the limitation of only effectively targeting cortical brain regions. Considering the critical role, supported by imaging studies and animal models, of subcortical brain areas, such as the striatum, thalamus, or hippocampus for motor and cognitive processes, there is a growing need for non-invasive approaches capable of reaching deeper brain structures (Miyachi et al., 1997). Currently, a novel, promising, innovative, and safe neuromodulation technique called transcranial temporal interference stimulation (tTIS) has been introduced (Figure 1), with the potential to address these challenges by selectively targeting deeper brain regions without impacting overlying structures (Wessel et al., 2023; Beanato et al., 2024; Vassiliadis et al., 2024). As a novel approach, it is not surprising that research on its application in human neurorehabilitation remains limited. This manuscript seeks to provide an overview of tTIS in the context towards application in neurorehabilitation, particularly for stroke and TBI, to address current challenges, and, most importantly, to provide a forward-looking perspective on its future clinical applications and transformative impact on the field. Additionally, it highlights emerging areas of research and upcoming studies that promise to advance our understanding and implementation of this innovative technology.