Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (2): 416-421.doi: 10.4103/1673-5374.346549

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Treatment of radiation-induced brain injury with bisdemethoxycurcumin

Yun-Qian Chang1, 2, #, Gui-Juan Zhou1, #, Hong-Mei Wen3, Duan-Qun He1, 4, Chen-Lin Xu1, 5, Ya-Rui Chen1, Yi-Hui Li1, Shuang-Xi Chen1, *, Zi-Jian Xiao1, *, Ming Xie1, *   

  1. 1Department of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China; 2Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China; 3Department of Nursing, Youxian People’s Hospital, Zhuzhou, Hunan Province, China; 4Department of Neurology, Shenzhen Baoan People’s Hospital (Group), The Second People’s Hospital, Shenzhen, Guangdong  Province, China; 5Department of Neurology, Xiangxi Autonomous Prefecture People’s Hospital, Jishou, Hunan Province, China
  • Online:2023-02-15 Published:2022-08-09
  • Contact: Ming Xie, PhD, c237423281@163.com; Zi-Jian Xiao, PhD, zijian6340@21cn.com; Shuang-Xi Chen, PhD, dnafenzi@163.com.
  • Supported by:
    The study was supported by the National Natural Science Foundation of China, No. 82002400 (to GJZ); Scientific Research Project of Hunan Health Committee, No. 20201911 and No. 20200469 (both to ZJX); Scientific Research Project of Hunan Health Committee, No. 20211411761 (to HMW); the Natural Science Foundation of Hunan Province, No. 2020JJ5512 (to GJZ); a grant from Clinical Medical Technology Innovation Guidance Project in Hunan Province, No. 2020SK51822 (to ZJX).

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Abstract: Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.

Key words: astrocytes, bisdemethoxycurcumin, brain edema, brain tumor, curcumin, learning and memory, neuronal injury, oxidative stress, radiation therapy, radiation-induced brain injury