Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury

doi:10.3969/j.issn.1673-5374.2013.01.009

Abstract

Abstract:

We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury.

Key words: neural regeneration, brain injury, Dickkopf-1, Wnt signaling pathway, cell apoptosis, β-catenin, glycogen synthase kinase-3&beta, protein, cerebral ischemia/reperfusion injury, grant-supported paper, neuroregeneration

Bin Liu, Jing Tang, Shiying Li, Yuqin Zhang, Yan Li, Xiaoliu Dong. Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury[J]. Neural Regeneration Research, doi: 10.3969/j.issn.1673-5374.2013.01.009.

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