Medium-intensity acute exhaustive exercise induces neural cell apoptosis in the rat hippocampus

doi:10.3969/j.issn.1673-5374.2013.02.004

Abstract

Abstract:

The present study assessed the influence of medium-intensity (treadmill at a speed of 19.3 m/min until exhaustion) and high-intensity (treadmill at a speed of 26.8 m/min until exhaustion) acute exhaustive exercise on rat hippocampal neural cell apoptosis. TUNEL staining showed significantly increased neural cell apoptosis in the hippocampal CA1 region of rats after medium- and high-intensity acute exhaustive exercise, particularly the medium-intensity acute exhaustive exercise, when compared with the control. Immunohistochemistry showed significantly increased expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bax in the hippocampal CA1 region of rats after medium- and high-intensity acute exhaustive exercise. Additionally, the ratio of Bax to Bcl-2 increased in both exercise groups. In particular, the medium-intensity acute exhaustive exercise group had significantly higher Bax and Bcl-2 protein expression and a higher Bax/Bcl-2 ratio. These findings indicate that acute exhaustive exercise of different intensities can induce neural cell apoptosis in the hippocampus, and that medium-intensity acute exhaustive exercise results in greater damage when compared with high-intensity exercise.

Key words: neural regeneration, brain injury, hippocampus, apoptosis, neuron, different intensities, acute exhaustive exercise, Bax, Bcl-2, grant-supported paper, photographs-containing paper, neuroregeneration

Shanni Li, Jin Liu, Hengmei Yan. Medium-intensity acute exhaustive exercise induces neural cell apoptosis in the rat hippocampus[J]. Neural Regeneration Research, 2013, 8(2): 127-132.

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