Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (10): 778-782.

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Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging

Huqing Wang, Haiqin Wu, Hena Guo, Guilian Zhang, Ru Zhang, Shuqin Zhan   

  1. Department of Neurology, Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • Received:2011-11-15 Revised:2012-02-28 Online:2012-04-05 Published:2012-04-05
  • Contact: Haiqin Wu, Master, Professor, Department of Neurology, Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China whq60@sohu.com
  • About author:Huqing Wang★, Master, Attending physician, Department of Neurology, Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China

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Abstract:

The present study observed changes in rat neural cells at various ages (3, 18, 24, and 30 months). With age, neural cells became large and were sparsely arranged, and the number of Nissl bodies decreased. In addition, hypoxia-inducible factor 1α expression increased with increasing age in hippocampal CA1 and CA3 regions, motor cortex, and the first subfolium, especially from 3 to 18 months. In the open-field test, grid crossing decreased with increasing age, especially from 18 months. The number of rearings reached a peak in the 18 months group, and then subsequently decreased. The results suggested that hypoxia-inducible factor 1α played an important role in the nervous system aging process.

Key words: aging, brain, hypoxia-inducible factor 1α, Nissl body, behavior