Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (8): 606-611.

Previous Articles     Next Articles

Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome

Liping Peng1, Jinghua Wang1, Lihong Zhang2, Pan Liu1, Min Wang1, Min Huang3, Shengnan Liu1, Pingping He1, Li Cui4, Mingxian Li1, Shao Wang2   

  1. 1 Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China
    2 Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China
    3 Department of Physiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China
    4 Department of Neurology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2011-08-15 Revised:2011-11-20 Online:2012-03-15 Published:2012-03-15
  • Contact: Mingxian Li, M.D., Professor, Chief physician, Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China; Li Cui, Doctor, Professor, Chief physician, Department of Neurology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China limingxian_118@163.com; chuili1967@163.com
  • About author:Liping Peng☆, M.D., Professor, Chief physician, Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China Liping Peng and Jinghua Wang equally contributed to this work.

PDF

807

Abstract:

In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus.

Key words: sleep apnea, obstructive, cerebellum, 5-hydroxytryptamine, insular cortex, habenular nucleus, Purkinje cells