Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (29): 2693-2702.doi: 10.3969/j.issn.1673-5374.2013.29.001

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Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage

Gang Chen1, Tong Hu1, 2, Qi Li1, Jianke Li1, Yang Jia1, Zhong Wang1   

  1. 1 Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
    2 Department of Neurosurgery, Yixing People’s Hospital, Yixing 214200, Jiangsu Province, China
  • Received:2013-05-06 Revised:2013-08-09 Online:2013-10-15 Published:2013-10-15
  • Contact: Zhong Wang, M.D., Professor, Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China, nju_neurosurgery@ 163.com.
  • About author:Gang Chen, M.D., Attending physician.

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Abstract:

Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid hemorrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage.

Key words:   neural regeneration, brain injury, synaptosomal-associated protein-25, subarachnoid hemorrhage, cognition, cortex, hippocampus, cerebellum, grants-supported paper, neuroregeneration