Abstract: Extensive neuronal cell death occurs during nervous system development to remove surplus, unwanted, and damaged cells. This is a highly regulated physiological process that plays a pivotal role in nervous system homeostasis and normal development. In some brain regions, more than half of the neurons are removed during normal development without interfering with the remaining cells. This gene-regulated neuronal cell deletion process is called programmed cell death (Fricker et al., 2018). However, under pathological conditions such as brain ischemia or hemorrhage and neurodegenerative and neuroinflammatory disorders, neuronal cell death may occur through gene-regulated cell death or accidental cell death in specific brain regions depending on the severity of the pathological stimuli. Accidental cell death is an uncontrolled or unavoidable biological process that involves immediate breakdown of cellular structures resulting from severe physiochemical or mechanical insult. Regulated cell death is closely integrated with signaling cascades and molecular processes that can be altered by pharmacological or genetic interventions (Cui et al., 2021).