Abstract: Several decades have passed since programmed-cell death (PCD) was identified. Apoptosis was first defined by Kerr in 1972, and later described by the Nobel Prices in Physiology or Medicine 2002, Sydney Brenner, John Sulston and Robert Horwitz, who defined genetic regulators of apoptosis (Diamantis et al., 2008). However, it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis, which he named necrobiosis, arguing that this form of cell death was completely different from the uncontrolled necrosis, suggesting the existence of two different types of cell death. Today, the knowledge in the field of cell death regulation is extensive, but still under continuous expansion.