Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (23): 2126-2133.doi: 10.3969/j.issn.1673-5374.2013.23.002

Previous Articles     Next Articles

Is longer sevoflurane preconditioning neuroprotective in permanent focal cerebral ischemia

Caiwei Qiu1, 2, Bo Sheng3, Shurong Wang4, Jin Liu2   

  1. 1 West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China
    2 Neuroscience Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    3 Department of Anesthesiology, Panzhihua Central Hospital, Panzhihua 617000, Sichuan Province, China
    4 Department of Neurology, the 452 People’s Liberation Army Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2013-04-07 Revised:2013-07-15 Online:2013-08-15 Published:2013-08-15
  • Contact: Jin Liu, M.D., Neuroscience Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, scujinliu@gmail.com.
  • About author:Caiwei Qiu, Ph.D.

PDF

1339

Abstract:

Sevoflurane preconditioning has neuroprotective effects in the cerebral ischemia/reperfusion model. However, its influence on permanent cerebral ischemia remains unclear. In the present study, the rats were exposed to sevoflurane for 15, 30, 60, and 120 minutes, followed by induction of perma-nent cerebral ischemia. Results demonstrated that 30- and 60-minute sevoflurane preconditioning significantly reduced the infarct volume at 24 hours after cerebral ischemia, and 60-minute sevoflurane preconditioning additionally reduced the number of TUNEL- and caspase-3-positive cells in the ischemic penumbra. However, 120-minute sevoflurane preconditioning did not show evident neuroprotective effects. Moreover, 60-minute sevoflurane preconditioning significantly at-tenuated neurological deficits and infarct volume in rats at 4 days after cerebral ischemia. These findings indicated that 60-minute sevoflurane preconditioning can induce the best neuroprotective effects in rats with permanent cerebral ischemia through the inhibition of apoptosis.

Key words: neural regeneration, brain injury, anesthesia, sevoflurane, preconditioning, cerebral ischemia, apoptosis, caspase-3, neuroregeneration