Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (31): 2895-2903.doi: 10.3969/j.issn.1673-5374.2013.31.002

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Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction

Sijie Li1, Yanbo Zhang2, Guo Shao3, Mingfeng Yang2, Jingzhong Niu2, Guowei Lv1, Xunming Ji1   

  1. 1 Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China
    2 Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 27100, Shandong Province, China
    3 Research Center of Biology and Medicine, Baotou Medical College, Baotou 014060, Inner Mongolia Autonomous Region, China
  • Received:2013-04-14 Revised:2013-08-17 Online:2013-11-05 Published:2013-11-05
  • Contact: Xunming Ji, M.D., Doctoral supervisor, Professor, Chief physician, Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China, jixm70@hotmail.com.
  • About author:Sijie Li, Master, Attending physician. Sijie Li and Yanbo Zhang contributed equally to this work.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 30870854; the Natural Science Foundation of Beijing, No. 7111003; and the Natural Science Foundation of Shandong Province, No. ZR2010HM029.

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Abstract:

Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cer-ebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we in-duced a photochemical model of cerebral infarction in an inbred line of mice (BALB/c). Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment. Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction, mainly in neurons and vascular endothelial cells. Hy-Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31. Moreover, hypoxic preconditioning reduced the infarct volume and improved neu-rological function in mice. These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra, which promoted angiogenesis.

Key words: neural regeneration, brain injury, hypoxic preconditioning, acute cerebral infarction, ischemic penumbra, vascular endothelial growth factor, CD31, angiogenesis, neuroprotection, grants- supported paper, neuroregeneration