Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (31): 2942-2950.doi: 10.3969/j.issn.1673-5374.2013.31.007

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Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion

Yunjun Yang1, Lingyun Gao2, Jun Fu2, Jun Zhang1, Yuxin Li1, Bo Yin1, Weijian Chen2, Daoying Geng1   

  1. 1 Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
    2 Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
  • Received:2013-07-20 Revised:2013-10-05 Online:2013-11-05 Published:2013-11-05
  • Contact: Daoying Geng, Professor, Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China, wzmcyyunjun@163.com.
  • About author:Yunjun Yang, Ph.D., Associate professor. Yunjun Yang and Lingyun Gao contributed equally to this work.
  • Supported by:

    This study was supported by Zhejiang Province Science and Technology Plan Project in China, No. 2012C37029; Public Welfare Technology Application Research Plan Project of Zhejiang Province in China, No. 2011C23021.

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Abstract:

Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffu-sion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially in-creased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion co-efficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3–24 hours after infarction. Apparent diffusion coefficient values at remote regions (cerebellum) varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.

Key words: neural regeneration, brain injury, cerebral ischemia, cerebral infarction, magnetic resonance imaging, apparent diffusion coefficient, middle cerebral artery occlusion, diffusion weighted imaging, infarction core, remote regions, diaschisis, grants-supported paper, neuroregeneration