Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (5): 534-539.doi: 10.4103/1673-5374.130084

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Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction

Yanlin Bi 1, 2, Shuyun Liu 2, Xinjuan Yu 3, Mingshan Wang 3, Yuelan Wang 1   

  1. 1 Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China
    2 Department of Anesthesiology, Shaoxing People’s Hospital, Shaoxing, Zhejiang Province, China
    3 Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China
  • Received:2014-01-28 Online:2014-03-12 Published:2014-03-12
  • Contact: Yuelan Wang, M.D., Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China, wyldgf@163.com.

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Abstract:

Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1–7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.

Key words: nerve regeneration, postoperative cognitive dysfunction, splenectomy, brain, aging, 5′adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, tumor necrosis factor-α, interleukin-1β, neural regeneration