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Figure 1｜Microphysiological model of NVU-on-a-chip.
NVU-on-a-chip as the next-generation platform for unraveling the pathological processes of ischemic stroke and advancing therapeutic screening: Recently published in Nature Biomedical Engineering, the NVU-on-a-chip successfully replicated the complex human brain microenvironment, specifically designed to mimic the conditions of ischemic stroke (Lyu et al., 2021). This microphysiological system integrates 3D cell co-culture technology and microfluidic technology to mimic the blood flow and interactions between cells in the NVU, especially in the brain capillary region. Comprising human brain microvascular endothelial cells (BMECs), pericytes, astrocytes, microglia, and neurons, the NVU-on-a-chip accurately captured crucial aspects of the human brain microenvironment, such as the integrity of the BBB, the presence of a heterocellular network, and the appropriate mechanical stimuli as a highly realistic and physiologically relevant model for investigating the intricate interactions within the NVU during the pathogenesis of ischemic stroke (Figure 1).