中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (7): 1431-1432.doi: 10.4103/1673-5374.385296

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

芯片上的神经血管单元:为干细胞治疗缺血性脑卒中提供接近人类疾病的模型

  

  • 出版日期:2024-07-15 发布日期:2023-11-28

The neurovascular unit-on-a-chip: modeling ischemic stroke to stem cell therapy

Seonghun Kim*, Minjun Kim, Gerald A. Grant, Wonjae Lee*#br#   

  1. Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA (Kim S, Kim M, Grant GA, Lee W)
    Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA (Grant GA, Lee W)
    Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC, USA (Grant GA, Lee W)
    Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA (Grant GA, Lee W)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Seonghun Kim, PhD, seonghun.kim@duke.edu; Wonjae Lee, PhD, wonjae.lee@duke.edu.
  • Supported by:
    This work was supported by the NIH National Cancer Institute career development award (K25CA201545, to WL).

摘要: https://orcid.org/0000-0003-3338-1156 (Seonghun Kim)
https://orcid.org/0000-0003-1524-2259 (Wonjae Lee) 

Abstract: The neurovascular unit and stem cell therapy in ischemic stroke: Ischemic stroke, accounts for approximately 85% of all stroke incidents and is a major global health burden. It is the leading cause of disability and death worldwide, posing immense societal and economic challenges due to the long-term care required for stroke survivors and the significant healthcare costs associated with its treatment and management (Amarenco et al., 2009). Ischemic stroke inflicts damage that spans multiple aspects, disrupts cerebral blood flow, and leads to a cascade of deleterious events including cellular excitotoxicity, oxidative stress, neuroinflammation, and subsequent neuronal degeneration (Macrez et al., 2011). The neurovascular unit (NVU), a minimal functional unit within the brain, encompasses neurons, astrocytes, microglia, oligodendrocytes, pericytes, and endothelial cells. This complex ensemble is pivotal in maintaining the blood-brain barrier (BBB) integrity and stabilizing the cerebral microenvironment. In the context of ischemic stroke, the NVU not only embodies the disease’s pathological spectrum but also significantly contributes to post-stroke restoration. Damage to the NVU during ischemic stroke disrupts its structural and functional integrity, increases BBB permeability, and induces neuroinflammatory responses. The intricate interactions among the NVU’s cellular and extracellular components are instrumental in tissue repair, angiogenesis, neurogenesis, and functional recovery following a stroke (Wang et al., 2021).