中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (25): 1954-1959.doi: 10.3969/j.issn.1673-5374.2012.25.005

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

叶酸减轻高同型半胱氨酸血症诱发的大鼠子痫前期症状

  

  • 收稿日期:2012-05-11 修回日期:2012-07-10 出版日期:2012-09-05 发布日期:2012-09-05

Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats

Jun Wang1, Yan Cui2,Jing Ge1, Meijing Ma3   

  1. 1 Department of Gynaecology and Obstetrics, the 202 Hospital of People’s Liberation Army, Shenyang 110003, Liaoning Province, China
    2 Department of Emergency Medicine, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
    3 Department of Gynaecology and Obstetrics, the Second People's Hospital of Tongliao, Tongliao 280000, Inner Mongolia Autonomous Region, China
  • Received:2012-05-11 Revised:2012-07-10 Online:2012-09-05 Published:2012-09-05
  • Contact: Jun Wang, the 202 Hospital of People’s Liberation Army, Shenyang 110003, Liaoning Province, China wj202fck@163.com
  • About author:Jun Wang☆, M.D., Associate chief physician, Master’s supervisor, the 202 Hospital of People’s Liberation Army, Shenyang 110003, Liaoning Province, China Jun Wang and Yan Cui contributed equally to this work.

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Abstract:

Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocystei-nemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of perhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia- induced preeclampsia in pregnant rats without influencing brain development of rat pups.

Key words: folic acid, preeclampsia, hyperhomocysteinemia, proteinuria, creatinine, preeclampsia-like symptom, pregnant rats, offspring, brain, nervous system, regeneration, neural regeneration