中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (25): 1985-1991.doi: 10.3969/j.issn.1673-5374.2012.25.010

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

去甲肾上腺素转运体基因与中国北方汉族人群抑郁症迟缓症状的关联

  

  • 收稿日期:2012-06-05 修回日期:2012-08-06 出版日期:2012-09-05 发布日期:2012-09-05

The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population

Xinrong Li1, Ning Sun1, 2, Yong Xu1, Yanfang Wang1, Suping Li1, Qiaorong Du1, Juyi Peng1, Jinxiu Luo1, Kerang Zhang1   

  1. 1 Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
    2 Nursing College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2012-06-05 Revised:2012-08-06 Online:2012-09-05 Published:2012-09-05
  • Contact: Kerang Zhang, M.D., Professor, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China krzhang_sxmu@vip.163.com
  • About author:Xinrong Li★, Master, Attending physician, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China Xinrong Li and Ning Sun contributed equally to this work.

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Abstract:

The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder. Consequently, the norepinephrine transporter gene is an attractive candidate in major depressive disorder research. In the present study, we evaluated the depression symptoms of subjects with major depressive disorder, who were all from the North of China and of Han Chinese origin, using the Hamilton Depression Scale. We examined the relationship between two single nucleotide polymorphisms in the norepinephrine transporter, rs2242446 and rs5569, and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program. rs5569 was associated with depressed mood, and the GG genotype may be a risk factor for this; rs2242446 was associated with work and interest, and the TT genotype may be a risk factor for loss of interest. Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population.

Key words: Norepinephrine transporter, major depressive disorder, quantitative trait locus, gene polymorphism, retardation symptoms, Hamilton Depression Scale, endophenotype, single nucleotide polymorphism, pathogenesis