中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (34): 3216-3224.doi: 10.3969/j.issn.1673-5374.2013.34.005

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

活血荣络片减少脑梗死组织中基质金属蛋白酶9的表达

  

  • 收稿日期:2013-05-21 修回日期:2013-11-15 出版日期:2013-12-05 发布日期:2013-12-05

Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue

Desheng Zhou1, Mei Li2, Hua Hu1, Yao Chen1, Yang Yang3, Jie Zhong1, Lijuan Liu1   

  1. 1 Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
    2 Department of Internal Medicine, Pingxiang Hospital of Traditional Chinese Medicine, Pingxiang 337000, Jiangxi Province, China
    3 Department of Neurology, People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China
  • Received:2013-05-21 Revised:2013-11-15 Online:2013-12-05 Published:2013-12-05
  • Contact: Mei Li, Studying for master’s degree, Department of Internal Medicine, Pingxiang Hospital of Traditional Chinese Medicine, Pingxiang 337000, Jiangxi Province, China, limeimay0@163.com.
  • About author:Desheng Zhou, M.D., Professor, Doctoral supervisor, Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China, 2478020529@qq.com.

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摘要：

天麻、白芷、忍冬藤、石菖蒲、木瓜、玄参、赤芍、桃仁按3:2:6:2:3:3:3:3比例制备的活血荣络片为治疗脑梗死的经验方。实验给予脑缺血模型大鼠中成药活血荣络片溶液灌胃治疗后，大鼠脑梗死体积减小，全脑组织中基质金属蛋白酶9的表达减少，大鼠神经功能明显改善，且活血荣络片作用效果优于临床常用药物磷酸吡哆醛丁咯地尔。提示活血荣络片可以通过脑组织调节基质金属蛋白酶9蛋白的表达，有效治疗脑梗死。

中国神经再生研究（英文版）杂志出版内容重点： 脑损伤；脊髓损伤；周围神经损伤；帕金森；神经影像；神经再生