中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (2): 117-118.doi: 10.4103/1673-5374.125338

• 观点:周围神经损伤修复保护与再生 •    下一篇

脊神经根撕脱:研究神经元及轴突损伤和再生的最佳模型

  

  • 收稿日期:2014-01-02 出版日期:2014-01-10 发布日期:2014-01-10

Spinal root avulsion: an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury

Carolin Ruven1, Tak-Kwong Chan1, Wutian Wu1, 2   

  1. 1 Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; 2  GHM Institute of CNS regeneration, Jinan University and The University of Hong Kong, Guangzhou, Guangdong Province, China
  • Received:2014-01-02 Online:2014-01-10 Published:2014-01-10
  • Contact: Wutian Wu, M.D., Professor, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong Special Administrative Region, China, wtwu@hku.hk.

摘要:

一个好的的神经损伤模型有助于研究神经损伤后的相关变化,可以为临床治疗提供参考。中国香港大学李嘉诚医学院解剖学系吴武田教授及所在团队对其实验室运用脊神经根撕脱模型在神经损伤研究中的系列工作做以回顾,指出他们建立的脊神经根撕脱模型可以方便观察脊髓损伤后神经元的死亡和生存现象,并且深入地研究轴突再生的机制。

Abstract:

Spinal root avulsion is an excellent model for studying the response of motoneurons to severe injury to their axons. In this model (‘Avulsion Model’), spinal roots are torn off from spinal cord without removing the vertebra at different levels of spinal segments, usually at cervical and lumbar segments. Step-by-step procedures are described in detail elsewhere. The Avulsion Model resembles very well brachial plexus injuries in human beings. Around 70% of severe brachial plexus injuries in human involved avulsion of one or more roots and the main causes of traumatic brachial plexus injuries were motor vehicle accidents, sport injuries and difficult deliveries. The Avulsion Model involves injury to both central nervous system (CNS) and peripheral nervous system (PNS) while nerve axotomy, transection and crush injuries only involve PNS.