中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (5): 460-461.doi: 10.4103/1673-5374.130056

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

外源性抑制剂促进代偿性轴突生长及脊髓损伤恢复

  

  • 收稿日期:2014-02-11 出版日期:2014-03-12 发布日期:2014-03-12

Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury

Jessica M. Meves, Binhai Zheng   

  1. Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA, USA
  • Received:2014-02-11 Online:2014-03-12 Published:2014-03-12
  • Contact: Binhai Zheng, Ph.D., Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093-0691, USA, binhai@ucsd.edu.

摘要:

中枢神经系统损伤后修复能力有限,很大程度上是因为轴突损伤后不能再生长。很少有实验能促进受损轴突的再生和受损后功能恢复。现有的大部分研究关注中枢神经系统损伤的文献都集中在受损轴突的再生修复神经回路,然而,但加州大学圣地亚哥分校的研究人员表明,从中枢神经系统损伤如脊髓损伤中的恢复,可部分由未受损神经的轴突生长来介导,而外在抑制剂可以促进中枢神经系统环境中这种未受损神经的轴突生长。揭示这是一种促进患者功能恢复的替代方法。

Abstract:

Recovery from injury to the CNS is limited, which is due in large part to the inability of axons to grow after injury. Unfortunately few experimental manipulations have been found that promote regeneration of damaged axons and functional recovery from injury. Nonetheless, targeting various axon growth inhibitors present in the CNS environment promotes compensatory growth of undamaged axons and functional recovery from experimental CNS injury, revealing an alternative approach to promoting functional recovery in patients.