中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (6): 577-578.doi: 10.4103/1673-5374.130089

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

牙髓干细胞促进受损视神经细胞再生

  

  • 收稿日期:2014-02-26 出版日期:2014-03-22 发布日期:2014-03-22

Dental pulp stem cells, a paracrine-mediated therapy for the retina

Ben Mead 1, 2, Ann Logan 1, Martin Berry 1, Wendy Leadbeater 1, Ben A. Scheven 2
  

  1. 1 Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    2 School of Dentistry, University of Birmingham, Birmingham B4 6NN, United Kingdom
  • Received:2014-02-26 Online:2014-03-22 Published:2014-03-22
  • Contact: Ben Mead, Molecular Neuroscience Group, Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, B15 2TT, United Kingdom, BXM813@bham.ac.uk.
  • Supported by:

    The studentship of Ben Mead was funded by the BBSRC (grant number BB/F017553/1) and the Rosetrees Trust.

摘要:

英国伯明翰大学Dr. Ben Scheven, Dr. Wendy Leadbeater 及 Ben Mead实验室研究发现,牙髓干细胞可以保护受损视网膜神经节细胞远离死亡并促进视神经轴突再生。
外伤及退行性疾病导致的视网膜神经节细胞受损是导致失明的主要原因。损伤或疾病后,作为生存信号的神经营养因子本应该沿着一个神经元的轴突迁移到胞体,但是,这种供应的丢失导致视网膜神经节细胞死亡。补充神经营养因子是极为重要的保护损伤视网膜神经节细胞免于死亡的方法。
《中国神经再生研究(英文版)》杂志2014年3月第6期杂志的文章中指出,牙髓干细胞自然表达多个神经营养因子,可补充视网膜神经节细胞丢失的神经营养因子,保护视网膜神经节细胞,避免死亡,也能促进轴突再生。Ben Mead 说,“细胞治疗是一种很有前途的治疗选择,因为它为受损神经元提供潜在的无限的多种生长因子” ,他还表示,“今后的研究将比较牙髓干细胞与其他干细胞在临床应用的作用及安全性”。

Abstract:

Injury to the retina and optic nerve leads to irreversible loss of retinal ganglion cells (RGCs) and irreparable damage to their axons which ultimately leads to blindness. Providing a sustained source of neurotrophic growth factors is required to promote their survival and regeneration. Transplanted dental pulp stem cells secrete multiple growth factors which protect RGCs from death after optic nerve injury and promote regeneration of their axons.