中国神经再生研究(英文版)

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

P2X7 受体与视神经元死亡密切相关

  

  • 收稿日期:2014-02-25 出版日期:2014-03-22 发布日期:2014-03-22

Role of P2X7 receptors in neuronal death in the retina

Tetsuya Sugiyama 1, 2   

  1. 1 Nakano Eye Clinic of Kyoto Medical Co-operative, Kyoto 604-8404, Japan
    2 Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan
  • Received:2014-02-25 Online:2014-03-22 Published:2014-03-22
  • Contact: Tetsuya Sugiyama, M.D., Ph.D., Nakano Eye Clinic of Kyoto Medical Co-operative, 2 Jurakukaitou-Cho, Nakagyo-Ku, Kyoto, 604-8404, Japan, tsugiyama@poh.osaka-med.ac.jp.

摘要:

嘌呤及其受体在眼部各结构的生理和病理学变化中扮演着重要角色。P2X7受体是近年来发现的、有独特特点的嘌呤受体家族中的一员。日本大阪医科大学Dr. Sugiyama实验室研究发现,P2X7受体可能在视网膜中神经元死亡中发挥重要作用。研究发现,P2X7 是一种重要的凋亡受体。在低浓度ATP 等激动剂刺激下可以引起选择性阳离子通道打开,允许钾、钠、钙等阳离子跨膜流动,而对二价阳离子表现出相对强的选择性,在低二价阳离子重复或者延长刺激使该通道形成孔洞,可以使大的有机分子通过,造成细胞凋亡。Sugiyama等人研究表明,视网膜神经节细胞损伤后,眼内压升高,激活眼内压急性升高可诱导P2X7受体表达增加和炎症细胞因子的表达增加,上调的炎性因子可能与视网膜神经节细胞死亡相关,眼内压上升使该受体被激活。Dr. Sugiyama 表明,“P2X7受体可能是药物治疗青光眼在内的眼部疾病的一个潜在的靶点,它可以防止神经元死亡”。

Abstract:

The P2X7 receptor is a member of the family of purinoceptors. In addition to its physiological roles, its stimulation has been reported to be involved in neuronal death in the retina. Its stimulation may also exert a deleterious effect on retinal ganglion cells in glaucomatous eyes, being associated with the up-regulation of inflammatory cytokine expression. P2X7 receptor is a potential therapeutic target of pharmacological strategies designed to prevent neuronal death in ocular diseases including glaucoma.