中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (7): 677-683.doi: 10.4103/1673-5374.131564

• 观点:脊髓损伤修复保护与再生 •    下一篇

丙烯醛可作为脊髓损伤后运动和感觉障碍治疗的新靶点

  

  • 收稿日期:2014-04-08 出版日期:2014-04-15 发布日期:2014-04-15

Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

Jonghyuck Park 1, 2, Breanne Muratori 2, Riyi Shi 1, 2   

  1. 1 Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA
    2 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
  • Received:2014-04-08 Online:2014-04-15 Published:2014-04-15
  • Contact: Riyi Shi, M.D., Ph.D., Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA, riyi@purdue.edu.

摘要:

丙烯醛是一种高反应性不饱和醛,已有的研究显示了其可显著改善运动和感觉功能障碍。美国普渡大学Riyi Shi教授所在的研究团队将重点介绍丙烯醛在脊髓损伤动物模型中对运动和感觉障碍的修复作用及机制理解的最新进展。也将讨论如何减弱脊髓损伤后由丙烯醛介导的神经元损伤及继发性疼痛的相关问题。

Abstract:

In the hours to weeks following traumatic spinal cord injuries (SCI), biochemical processes are initiated that further damage the tissue within and surrounding the initial injury site: a process
termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI.

Key words: oxidative stress, spinal cord injury, 3-hydrxypropyl mercapturic acid, acrolein-lysine adduct, hydralazine