中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (7): 684-687.doi: 10.4103/1673-5374.131565

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

干细胞生物学最新研究进展

  

  • 收稿日期:2014-04-10 出版日期:2014-04-15 发布日期:2014-04-15

A brief review of recent advances in stem cell biology

Jinhui Chen 1, Libing Zhou 2, Su-yue Pan 3   

  1. 1 Stark Neuroscience Research Institute and Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    2 Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, Guangdong Province, China
    3 Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • Received:2014-04-10 Online:2014-04-15 Published:2014-04-15
  • Contact: Jinhui Chen, M.D., Ph.D., Stark Neuroscience Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, 980 W. Walnut Street, Indianapolis, IN 46202, USA, Chen204@iupui.edu.
  • Supported by:

    The study was supported by NIH/NINDS R01-NS043246, P30-NS045758, the International Spinal Research Trust (STR-100) and the Ohio State University College of Medicine.

摘要:

干细胞研究不断呈现的新进展将为生物学和未来的临床应用带来极大机遇。干细胞可以在体内复制其他多种细胞,可在治疗阿尔茨海默病、修复脊髓损伤、治疗肾脏、肝脏和肺部疾病与使受损的心脏愈合等方面提供无限希望,其潜力巨大。美国印第安纳大学医学院Jinhui Chen教授表示这一领域的深入研究目前仍面临着包括生物学、伦理学、法律、政治和财政等方面的多重挑战,而这些问题的最终解决将决定该研究的成功与否以及其在未来医学界的潜在意义。

Abstract:

Stem cells have the remarkable potential to develop into many different cell types, essentially without limit to replenish other cells as long as the person or animal is still alive, offering immense hope of curing Alzheimer’s disease, repairing damaged spinal cords, treating kidney, liver and lung diseases and making damaged hearts whole. Until recently, scientists primarily worked with two  kinds of stem cells from animals and humans: embryonic stem cells and non-embryonic “somatic” or “adult” stem cells. Recent breakthrough make it possible to convert or “reprogram” specialized adult cells to assume a stem stem-like cells with different technologies. The review will briefly discuss the recent progresses in this area.

Key words: stem cell, adult stem cell, embryonic stem cell, somatic cell nuclear transfer, induced pluripotent stem cell, stimulus-triggered acquisition of pluripotency