中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (7): 759-760.doi: 10.4103/1673-5374.131583

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

神经黑素敏感超高场磁共振成像:描绘出神经黑素的组织特征

  

  • 收稿日期:2014-04-15 出版日期:2014-04-15 发布日期:2014-04-15

Neuromelanin-sensitive magnetic resonance imaging: a promising technique for depicting tissue characteristics containing neuromelanin

Ken Nakamura, Keizo Sugaya   

  1. Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
  • Received:2014-04-15 Online:2014-04-15 Published:2014-04-15
  • Contact: Keizo Sugaya, Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo 183-0042, Japan,keizo_sugaya@member.metro.tokyo.jp.

摘要:

尽管神经黑素的生物功能尚未确定,但神经元中神经黑素具有的选择性易损能力对原发性帕金森病患者来说可以在神经退行性疾病中起到神经元损伤,使之死亡性凋亡的重要作用。日本东京都神经医院Keizo Sugaya博士等人的研究表明超高场磁共振成像(MRI)系统的T1加权敏感图像具有很高的空间分辨率,可以描绘出含有的神经黑素。他们回顾了神经黑素敏感MRI检查在原发性帕金森病和相关疾病中的应用价值,并指出神经黑素可能会成为诊断原发性帕金森病的潜在生物标志物。

Abstract:

Although the biological function of neuromelanin has not yet been determined, the selective vulnerability of neuromelanin-containing neurons in patients with Idiopathic Parkinson’s disease (IPD) suggests a role for this pigment in neurodegeneration. Dr. Keizo Sugaya from Tokyo Metropolitan Neurological Hospital in Japan shows that recently developed ultra-high-field magnetic resonance imaging (MRI) systems produce T1-weighted neuromelanin-sensitive images with very high spatial resolution, enabling the depiction of tissue containing neuromelanin. Here we review recent advances in neuromelanin-sensitive MRI in IPD and related conditions suggesting that neuromelanin may be a potential diagnostic biomarker for IPD.