中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (11): 1104-1107.doi: 10.4103/1673-5374.135308

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

验证银杏叶提取物促进缺血性脑损伤修复与再生的研究

  

  • 收稿日期:2014-05-16 出版日期:2014-06-12 发布日期:2014-06-12

Repair and regeneration properties of Ginkgo biloba after ischemic brain injury

Aparna Raghavan, Zahoor A. Shah   

  1. Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
  • Received:2014-05-16 Online:2014-06-12 Published:2014-06-12
  • Contact: Zahoor A. Shah, Ph.D., Department of Medicinal and Biological Chemistry, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA, zahoor.shah@utoledo.edu.

摘要:

银杏叶提取物对症治疗老年痴呆症的研究已经进行到临床试验阶段,但其对缺血性脑损伤的修复作用研究较少。银杏叶提取物EGB 761不但可以增加卒中后小鼠神经干细胞数量,而且能够促进神经干细胞向缺血区迁移。银杏叶提取物EGB 761也能够增加触发Wnt/ Wnt/β-catenin 通路的Wnt表达,促进内源性新生。因此,作为天然药物,银杏叶提取物可能成为促进神经再生的替代方法。

Abstract:

Ginkgo Biloba (G. biloba) is a widely studied herb for the treatment of neurological disorders, its use as a symptomatic treatment for dementia has been established in clinical trials. However, its use for the treatment of ischemic stroke in the clinic is still equivocal. EGb 761-treated mice not only showed an increase in the number of NSCs post-stroke, but the majority of them were found in the proximity of the injury site or penumbra area. EGb 761 also enhanced the expression of Wnt, the ligand that is responsible for triggering the canonical Wnt pathway or the Wnt/β-catenin pathway, which constitutes one of the primary signaling mechanisms overseeing endogenous neurogenesis. Thus, EGb 761 can offer a diverse trove of potential drug leads that could someday change the way we think of nerve regeneration and the use of complementary and alternative medicine.