中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (11): 1110-1111.doi: 10.4103/1673-5374.135310

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

突触多巴胺神经末梢甲基化:致突触活性降低抑或促进神经发生与再生

  

  • 收稿日期:2014-06-04 出版日期:2014-06-12 发布日期:2014-06-12

Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions

Clivel G. Charlton   

  1. Department of Neuroscience and Pharmacology, Meharry Medical College, 1005 DB Todd Blvd., Nashville, TN, USA
  • Received:2014-06-04 Online:2014-06-12 Published:2014-06-12
  • Contact: Clivel G. Charlton, Ph.D., Department of Neuroscience and Pharmacology, Meharry Medical College, 1005 DB Todd Blvd., Nashville, TN 37208, USA, ccharlton@mmc.edu.
  • Supported by:

    NIH RO1 NS041674 and U54NS041071.

摘要:

突触多巴胺负责控制调节一些复杂和特殊功能,包括动作,行为,情绪,认知,以及最近证实的神经发生与再生。突触多巴胺甲基化,将导致渐进性突触多巴胺活性降低和与受体结合的甲基化,并导致突触多巴胺活动的突然抑制。突触多巴胺受体蛋白甲基化是一种稳定现象,可能有助于逐渐下调突触多巴胺活性,导致与年龄相关的运动功能障碍。来自美国梅哈里医学院的Clivel G. Charlton教授将这一观点与多年的研究结果以及最近的发现假说相结合,证实多巴胺神经末梢基化,可能有助于解释突触多巴胺能够控制监管哪些功能,突触多巴胺甲基化,可以为管理与突触多巴胺功能障碍相关的疾病提供更好的治疗方法。此外,也有研究表示发现帕金森病中的突触多巴胺耗竭前体细胞可以促进神经发生与神经再生。调节突触多巴胺功能的多重开关,这一概念是十分新颖的,需要有更多的深入研究对这一方向进行观察。

Abstract:

Synaptic dopamine (DA) controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesisand neuroregeneration. The methylation of DA receptor protein is a stable phenomenon that may serve to progressively down-regulate DA synaptic activity, causing age-related decline in movements. Prof. Clivel G. Charlton , who comes from Meharry Medical College in USA ties this perspective together long-established findings, recent discoveries and a hypothesis to show that methylation, along with the standard release and uptake processes for DA, may help to explain the fidelity by which the functions that DA controls are regulated. Accepting the role of methylation in the synaptic activity of DA may lead to better ways of managing disorders related to DA synaptic functions. Moreover, the finding that DA depletion impairs precursor cell proliferation in PD corresponds with reports that DA promotes neurogenesis and neuroregeneration. The multiple-switch-concept in the regulation of DA synaptic functions is novel, requires further investigation.