中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (12): 1177-1179.doi: 10.4103/1673-5374.135322

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

转接策略结合轴突再生将是脊髓损伤修复有希望的疗法

  

  • 收稿日期:2014-05-23 出版日期:2014-06-24 发布日期:2014-06-24

Relay strategies combined with axon regeneration: a promising approach to restore spinal cord injury

Shaoping Hou   

  1. Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA
  • Received:2014-05-23 Online:2014-06-24 Published:2014-06-24
  • Contact: Shaoping Hou, Ph.D., Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA, shaoping.hou@drexelmed.edu.

摘要:

几十年来,许多研究都强调轴突再生对修复外伤性脊髓损伤的重要性,作为中断的神经通路,它们必须被重新连接来帮助感觉和自主神经功能的恢复。该方面的实验方法从药物治疗到细胞移植再到遗传干预。如果受损的轴突再生长距离能以突触的形式到达目标神经元,并导致明显的功能改善,这将是一项非凡的研究成就。来自美国德雷克塞尔大学的Shaoping Hou 博士认为预期能够完成成功再生的距离非常有限,仅有轴突再生可能并不足以修复受损的功能。在外部刺激条件下,皮质脊髓束却仍不能生长或对刺激不太敏感,即使是终端最长的感觉轴突再生其距离也不足以到达目标神经元。因此要重新建立神经通路,引进主导或嫁接神经元可能会是转接脊髓上信号传递到目标神经元的必要方法。

Abstract:

For decades, numerous investigations have only focused on axon regeneration to restore function after traumatic spinal cord injury (SCI), as interrupted neuronal pathways have to be reconnected for sensorimotor and autonomic recovery to occur. Experimental approaches have ranged from drug delivery and cell transplantation to genetic manipulations. Certainly, it would be an extraordinary achievement for injured axons to regenerate over long distances, to form synapses with target neurons, and to result in dramatic functional improvement. Dr. Shaoping Hou from Drexel University in USA considered that these efforts have been rewarded with limited success to date suggesting that axon regeneration alone may be insufficient to repair compromised functions. Upon exogenous stimulation, corticospinal tract (CST) axons do not or are less responsive. However, even terminals of the longest regenerated sensory axons are usually far from the original target. To reestablish neuronal pathways, introduction of a new host or graft-derived neuron may therefore be necessary to relay supraspinal signal transmission to target neurons.