中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (14): 1333-1336.doi: 10.4103/1673-5374.137582

• 观点:周围神经损伤修复保护与再生 •    下一篇

骨骼肌源性多能干细胞桥接修复长节段损伤的周围神经

  

  • 收稿日期:2014-07-04 出版日期:2014-07-25 发布日期:2014-07-25

Bridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells

Tetsuro Tamaki   

  1. Muscle Physiology & Cell Biology Unit, Department of Regenerative Medicine, Division of Basic Clinical Science, Tokai University School of
    Medicine, Isehara, Japan
  • Received:2014-07-04 Online:2014-07-25 Published:2014-07-25
  • Contact: Tetsuro Tamaki, Ph.D., Muscle Physiology and Cell Biology Unit, Department of Regenerative Medicine, Division of Basic Clinical Science, Tokai University School of Medicine, 143-Shimokasuya, Isehara, Kanagawa 259-1143, Japan,tamaki@is.icc.u-tokai.ac.jp.
  • Supported by:

    This work was supported by a 2013 Tokai University School of Medicine, Project Research Grant.

摘要:

日本东海大学基础学院再生医学系肌肉生理学及细胞生物学组Dr. Tetsuro Tamaki所在团队,从骨骼肌中分离出干细胞,并将其命名为骨骼肌源性多能干细胞。骨骼肌源性多能干细胞在受损外周神经处能分化为雪旺氏束膜和/神经内膜细胞、血管周细胞、内皮细胞和平滑肌细胞。Dr. Tetsuro Tamaki研究发现,与健康自体神经移植相比,神经导管复合骨骼肌源性多能干细胞桥接更有利于周围神经轴突再生,可修复长节段周围神经缺损。作者认为,此方法的应用将极大提高人损伤周围神经的治疗效果。

Abstract:

Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing superior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacrifice of healthy nerves or loss of related functions for repairing peripheral nerve injury.

Key words: peripheral nerve support cells, Schwann cells, perineurium, endoneurium, cytokine, paracrine effect, blood vessel formation