中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (14): 1341-1346.doi: 10.4103/1673-5374.137585

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

脂肪干细胞可促进损伤周围神经的再生:我们在解决的障碍

  

  • 收稿日期:2014-06-10 出版日期:2014-07-25 发布日期:2014-07-25

Adipose derived stem cells and nerve  regeneration

Alessandro Faroni 1, Richard JP Smith 1, Adam J Reid 1, 2   

  1. 1 Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK
    2 Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK
  • Received:2014-06-10 Online:2014-07-25 Published:2014-07-25
  • Contact: Alessandro Faroni, Ph.D., Blond McIndoe Laboratories, Institute of Inflammation and Repair - University of Manchester, 3.107 Stopford Building, Oxford Road, Manchester M13 9PT, UK, alessandro.faroni@manchester.ac.uk.

摘要:

临床上周围神经损伤修复的研究主要着重于自体神经移植。生物工程神经移植物复合细胞外基质及生长因子,或细胞移植修复周围神经损伤已成为周围神经损伤修复研究的热点问题。脂肪干细胞已被证实具有成脂肪,成骨,成软骨等多种分化潜能。因其材料来源广泛,取材容易,分化为神经元能力强,伦理学争议少等优点,使其成为神经导管上覆盖的优秀种子细胞。特异性抑制P2X7受体能够拯救ATP诱发细胞死亡,这可能成为解决神经损伤处移植的干细胞成活率低的问题。作者认为,此项研究结果可为周围神经修复结合干细胞疗法的发展指出新的方向。

Abstract:

Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts.

Key words: peripheral nerve injury, adipose derived stem cells, nerve guidance tubes, bioengineered nerve graft, axonal regeneration, Schwann cell, cell therapy, nerve repair