中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (15): 1422-1424.doi: 10.4103/1673-5374.139456

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

黄体酮修复脊髓损伤的潜力

  

  • 收稿日期:2014-07-21 出版日期:2014-08-12 发布日期:2014-08-12

Give progesterone a chance

Florencia Labombarda 1,2, Daniel Garcia-Ovejero 3   

  1. 1 Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine CONICET, Vuelta de Obligado 2490, Buenos Aires, Argentina
    2 Departament of Human Biochemistry, School of Medicine, Buenos Aires University, Paraguay 2155, Buenos Aires, Argentina
    3 Neuroinflammation Laboratory, National Hospital For Paraplegics, (SESCAM), Toledo, Spain
  • Received:2014-07-21 Online:2014-08-12 Published:2014-08-12
  • Contact: Florencia Labombarda, Ph.D., Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine CONICET, Vuelta de Obligado 2490, Buenos Aires, Argentina and Departament of Human Biochemistry School of Medicine, Buenos Aires University, Paraguay 2155, Buenos Aires, Argentina, florlabombarda@gmail.com.

摘要:

脊髓损伤造成的神经损伤可能会导致感觉和运动功能丧失(截瘫或四肢瘫痪),感染,膀胱及肠道功能丧失,心脏和呼吸功能障碍以及神经性疼痛的并发。创伤性脑损伤在病理特征上与外伤性脊髓损伤极其相似。

Abstract:

There is currently no standard pharmacological treatment for spinal cord injury. Here, we suggest that progesterone, a steroid hormone, may be a promising therapeutical candidate as it is already for traumatic brain injury, where it has reached phase II clinical trials. We rely on previous works showing anti-inflammatory, neuroprotective and promyelinating roles for progesterone after spinal cord injury and in our recent paper, in which we demonstrate that progesterone diminishes lesion, preserves white matter integrity and improves locomotor recovery in a clinically relevant model of spinal cord lesion.