中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (16): 1498-1501.doi: 10.4103/1673-5374.139471

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

神经延长促进损伤周围神经的再生

  

  • 收稿日期:2014-06-28 出版日期:2014-08-22 发布日期:2014-08-22

Peripheral nerve lengthening as a regenerative strategy

Kenneth M. Vaz 1, Justin M. Brown 2, Sameer B. Shah 3   

  1. 1 Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, USA
    2 Department of Neurosurgery, University of California, San Diego, La Jolla, CA, USA
    3 Departments of Orthopaedic Surgery and Bioengineering, University of California, San Diego, La Jolla, CA, USA
  • Received:2014-06-28 Online:2014-08-22 Published:2014-08-22
  • Contact: Sameer B. Shah, Ph.D., Departments of Orthopaedic Surgery and Bioengineering, University of California, 9500 Gilman Drive, MC 0863, La Jolla, CA 92093, USA, sbshah@ucsd.edu.
  • Supported by:

    This work was supported by a grant from Department of Defense (W81XWH-10-1-0773), National Science Foundation (CBET1042522), and a grant from the National Skeletal Muscle Research Center at UCSD.

摘要:

周围神经损伤后局部微环境对损伤神经的再生起重要作用。最新研究表明,周围神经损伤后适度的张力可以促进轴突再生。美国加州大学圣地亚哥分校矫形外科与生物工程系Sameer B. Shah博士假设,近端未受损的神经可以向损伤远侧神经伸长,并且忠实地再现体内和体外创建的机械环境,这种神经延长可以跨越神经缺损,确保解剖和功能匹配到远端残端并可能加速功能恢复。作者研究团队据此研制出新型的固定器,能线性拉长近端残端向远端残端并加速与远端重新连接,促进损伤周围神经的修复与再生。

 

Abstract:

Peripheral nerve injury impairs motor, sensory, and autonomic function, incurring substantial financial costs and diminished quality of life. For large nerve gaps, proximal lesions, or chronic nerve injury, the prognosis for recovery is particularly poor, even with autografts, the current gold standard for treating small to moderate nerve gaps. In vivo elongation of intact proximal stumps towards the injured distal stumps of severed peripheral nerves may offer a promising new strategy to treat nerve injury. This review describes several nerve lengthening strategies, including a novel internal fixator device that enables rapid and distal reconnection of proximal and distal nerve stumps.

Key words: peripheral nerve, nerve regeneration, nerve injury, nerve transfer, mechanical loading, biomedical device