Naringin is a well-known flavanone glycoside of grapefruits and citrus fruits. It has been reported that naringin possess neuroprotective effect against neurodegenerative disorders through modulating the oxidative stress and inflammatory responses. Although these evidences suggest that naringin may be a potential natural compound involved in the prevention and treatment against neurodegenerative diseases, it has not been clarified so far whether naringin has beneficial effects against degeneration of the nigrostriatal dopaminergic (DA) projection in the adult brain, which is associated with Parkinson’s disease. Therefore, we have recently investigated whether daily intraperitoneal injection of naringin can have neuroprotective roles in a rat model of 1-methyl-4-phenylpyridinium (MPP+)-induced Parkinson’s disease. Our results have showed that naringin treatment significantly increases glial cell line-derived neurotrophic factor (GDNF) expression and mammalian target of rapamycin complex 1 (mTORC1) activity in the nigral DA neurons, and naringin-induced production of GDNF contributes to the protection of the nigrostriatal DA projection in a neurotoxin model of Parkinson’s disease (Leem et al., 2014). Moreover, naringin decreases the level of tumor necrosis factor-alpha (TNF-α) in microglia increased by MPP+-induced neurotoxicity. Taken together, our findings suggest that naringin may be a potential natural product to prevent degeneration of the nigrostriatal DA projection in the adult brain. This prospect is reported in Neural Regeneration Research (Vol. 9, No.16, 2014).
Article: "Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain " Un Ju Jung1, Sang Ryong Kim2, 3, 4, 5 (1 Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea; 2 School of Life Sciences, Kyungpook National University, Daegu, Korea; 3 BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea; 4 Institute of Life Science & Biotechnology, Kyungpook National University, Daegu, Korea; 5 Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea)
Jung UJ, Kim SR. Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain.. Neural Regen Res. 2014;9(16):1514-1517.
Contact: Meng Zhao
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柚皮苷是来自葡萄柚和柑橘类水果提取出的黄酮苷。研究表明，柚皮苷通过调节氧化应激和炎症反应具有抗神经退行性疾病的神经保护作用，但迄今为止关于柚皮是否具有对成体大脑黑质纹状体多巴胺保护作用的研究较少。因此，韩国庆北国立大学生命科学院脑科学及工程学研究所Sang Ryong Kim博士设计了每日腹腔注射柚皮苷，以期认识对帕金森氏病大鼠模型的神经保护作用。结果表明，柚皮苷治疗显著增加黑质多巴胺神经元神经胶质细胞源性神经营养因子表达和雷帕霉素复合物1（mTORC1）的活性表达，并且，柚皮苷诱导帕金森病大鼠模型中神经胶质细胞源性神经营养因子保护黑质纹状体多巴胺。此外，柚皮苷降低了神经毒性导致的小胶质细胞内肿瘤坏死因子-α的水平。研究结果表明，柚皮苷可能是潜在的用于预防神经退行性疾病与帕金森病的天然产品。此观点发表在《中国神经再生研究（英文版）》2014年8月第16期杂志上。
Article: "Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain " Un Ju Jung1, Sang Ryong Kim2, 3, 4, 5 (1 Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea; 2 School of Life Sciences, Kyungpook National University, Daegu, Korea; 3 BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea; 4 Institute of Life Science & Biotechnology, Kyungpook National University, Daegu, Korea; 5 Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea)
Jung UJ, Kim SR. Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain.. Neural Regen Res. 2014;9(16):1514-1517.
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