Both in AD and in its animal models the loss of neuronal plasticity is known to precede any overt formation of A? plaques and hyperphosphorylated (p) tau neurofibrillary tangles. Furthermore, the AD brain, in which the hippocampus is the most affected area of the brain and an area of the human brain where neurogenesis is known to occur throughout life, responds to neurodegeneration by stimulating neurogenesis. However, because of the lack of a proper neurotrophic microenvironment of the hippocampus this effort of the AD brain to replace lost neurons with new is unsuccessful (Li et al., 2008). Dr. Khalid Iqbal, who comes from New York State Institute for Basic Research in Developmental Disabilities, USA suggests one potential rational therapeutic approach to AD and other neurodegenerative conditions is to provide a neurotrophic environment in the brain that can materialize into successful neurogenesis and rescue neuronal plasticity deficit. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 16, 2014).
Article: “ Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer’s disease and related neurodegenerative conditions" by Khalid Iqbal, Syed Faraz Kazim, Silvia Bolognin, Julie Blanchard (Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA)
Iqbal K, Kazim SF, Bolognin S, Blanchard J. Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer disease and related neurodegenerative conditions. Neural Regen Res. 2014;9(16):1518-1519.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
