Alzheimer’s disease is closely associated with disorders of neurogenesis in the brain, and growing evidence supports the involvement of immunological mechanisms in the development of the disease. However, at present, the role of T cells in neuronal regeneration in the brain is unknown. Jing Liu and co-workers from Southern Medical University in China discovered that T cells promote hippocampal neurogenesis in Alzheimer’s disease and T-cell immunodeficiency restricts neuronal regeneration in the hippocampus. The mechanism underlying the promotion of neuronal regeneration by T cells is mediated by an increased expression of peripheral T cells and central microglial cytokines in Alzheimer’s disease mice. Their findings which have been reported in the Neural Regeneration Research (Vol. 9, No. 16, 2014) provide an experimental basis for understanding the role of T cells in Alzheimer’s disease.
Article: " T cells promote the regeneration of neural precursor cells in the hippocampus of Alzheimer’s disease mice," by Jing Liu1, 2, Yuxin Ma2, Sumin Tian2, Li Zhang2, Mengmeng Zhao2, Yaqiong Zhang2, Dachuan Xu1 (1 Department of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China;2 Department of Human Anatomy, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China)
Liu J, Ma YX, Tian SM, Zhang L, Zhao MM, Zhang YQ, Xu DC. T cells promote the regeneration of neural precursor cells in the hippocampus of Alzheimer’s disease mice. Neural Regen Res. 2014;9(16):1541-1547.
Contact: Meng Zhao
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Neural Regeneration Research
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