中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (17): 1573-1577.doi: 10.4103/1673-5374.141778

• 观点:神经损伤修复保护与再生 •    下一篇

细胞外基质与人工神经支架:对神经再生的承诺

  

  1. 1 Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    2 University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • 收稿日期:2014-08-04 出版日期:2014-09-16 发布日期:2014-09-16

Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration

Christian B. Ricks 1, Samuel S. Shin 1, Christopher Becker 2, Ramesh Grandhi 1   

  • Received:2014-08-04 Online:2014-09-16 Published:2014-09-16
  • Contact: Ramesh Grandhi, M.D., Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 200 Lothrop St, Pittsburgh, PA 15213, USA, rameshmgrandhi@gmail.com.

Abstract:

Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent  developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting.

Key words: extracellular matrix, neurogenesis, scaffolds, neural stem cells