中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (17): 1643-1648.doi: 10.4103/1673-5374.141793

• 综述:脑损伤修复保护与再生 • 上一篇    

干细胞移植治疗脑卒中: 现状、趋势及发展

  

  • 收稿日期:2013-11-30 出版日期:2014-09-16 发布日期:2014-09-16

Stem cell transplantation for treating stroke: status, trends and development

Wenxin Huo, Xiaoyang Liu, Cheng Tan, Yingying Han, Chunyang Kang, Wei Quan, Jiajun Chen   

  1. Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
  • Received:2013-11-30 Online:2014-09-16 Published:2014-09-16
  • Contact: Jiajun Chen, M.D., Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China, chenjiajun999@sina.com.

Abstract:

The developing approaches of thrombolytic therapy, endovascular treatment, neuroprotective therapy, and stem cell therapy have enabled breakthroughs in stroke treatment. In this study, we summarize and analyze trends and progress in stem cell transplantation for stroke treatment by retrieval of literature from Thomson Reuters Web of Science database, the NIH Clinical Trial Planning Grant Program, and Clinical Trials Registration Center in North America. In the last 10 years, there has been an increasing number of published articles on stem cell transplantation for stroke treatment. In particular, research from the USA and China has focused on stem cell transplantation. A total of 2,167 articles addressing stem cell transplantation for stroke treatment from 2004 to 2013 were retrieved from the Thomson Reuters Web of Science database. The majority of these articles were from the USA (854, 39.4%), with the journal Stroke publishing the most articles (145, 6.7%). Of the published articles, 143 were funded by the National Institutes of Health (accounting for 6.6% of total publications), and 91 by the National Natural Science Foundation of China. Between 2013 and 2014, the National Institutes of Health provided financial support ($130 million subsidy) for 329 research projects on stroke therapy using stem cell transplantation. In 2014, 215 new projects were approved, receiving grants of up to $70,440,000. Ninety clinical trials focusing on stem cell transplantation for stroke were registered in the Clinical Trial Registration Center in North America, with 40 trials registered in the USA (ranked first place). China had the maximum number of registered research or clinical trials (10 projects).

Key words: nerve regeneration, stem cell, stroke, transplantation, neural stem cell, bone marrow mesenchymal stem cell, umbilical cord blood stem cell, embryonic stem cell, neural regeneration