中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (19): 1708-1711.doi: 10.4103/1673-5374.143410

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

神经营养因子:从神经发育调节到帕金森病治疗的新疗法

  

  • 收稿日期:2014-10-09 出版日期:2014-10-15 发布日期:2014-10-15

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson’s disease

Shane V. Hegarty, Gerard W. O’Keeffe, Aideen M. Sullivan   

  1. Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland
  • Received:2014-10-09 Online:2014-10-15 Published:2014-10-15
  • Contact: Aideen M. Sullivan, Ph.D., Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland, a.sullivan@ucc.ie.Gerard W. O’Keeffe, Ph.D., Department of Anatomy and Neuroscience, Biosciences Institute, Universiy College Cork, Cork, Ireland, g.okeeffe@ucc.ie.

摘要:

帕金森病是最常见的神经退行性疾病之一,全球有超过10万帕金森病患者。帕金森病的发病率会随着年龄的增长而增高,而由于人类平均寿命的明显延长,到2040年该病发病率预计将提高一倍。帕金森病是一种运动障碍疾病,会破坏负责调节自由运动的神经回路。尽管已有了几十年的研究,但帕金森病仍然无法治愈。爱尔兰科克大学的Gerard W. O’Keeffe博士指出目前对帕金森病的治疗方法多为多巴胺替代策略,这种方法会在有限的时间内对症状有所改善,然而神经退变仍在继续。现在,两种最有前景的疾病改善治疗方法是:通过给予神经营养因子的神经保护策略保护并使仍然存活的黑质纹状体多巴胺途径再生,和通过移植新的多巴胺神经元来取代那些已丢失的神经元,以此实现神经修复与神经再生。随着使用神经营养因子的临床试验的展开,这一方法将在帕金森病的治疗中表现出其潜力。

Abstract:

Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson’s disease. In Parkinson’s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.

Key words: Parkinson’s disease, neuroprotection, neurotrophic factors, nervous system development, nigrostriatal dopaminergic neurons, glial cell line-derived neurotrophic factor, neurturin, growth/differentiation factor 5