中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (4): 534-536.doi: 10.4103/1673-5374.155412

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

以再灌注为中心治疗缺血性脑卒中的临床前研究:谁在保护受损神经元?

  

  • 收稿日期:2015-03-02 出版日期:2015-04-22 发布日期:2015-04-22

Towards reperfusion-centric preclinical stroke research: outside the box of “reperfusion injury”

Chia Yi Kuan, Yu Yo Sun   

  1. Department of Pediatrics, Children’s Healthcare of Atlanta, Division of Neurology, and the Center for Neurodegenerative Diseases (CND), The Emory University School of Medicine, GA, USA (Kuan CY)
    Department of Pediatrics, Children’s Healthcare of Atlanta,
    Division of Neurology, The Emory University School of Medicine, GA, USA (Sun YY)
  • Received:2015-03-02 Online:2015-04-22 Published:2015-04-22
  • Contact: Chia-Yi Kuan, M.D., Ph.D.,Alex.kuan@emory.edu.
  • Supported by:

    This study was supported by the NIH grant NS084744 to YK. We thank all collaborators who contributed to our research papers upon which the present commentary is based.

摘要:

该文显示了组织型纤溶酶原激活物和依达拉奉协同效应对自发血栓性脑卒中模型的作用。他在该文中想要强调的是,“目前很难在神经保护治疗方面从动物模型转化到临床实践,在很大程度上,这是由于过分依赖机械梗阻的脑卒中模型,其既不产生更多的血液凝固,也不响应组织型纤溶酶原激活物的溶栓治疗”。因此,他认为有必要强调“血栓为中心的临床前脑卒中研究”来填充基础到临床转化方面的空白。这在该领域内是一种相当前卫的想法。