中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (4): 529-533.doi: 10.4103/1673-5374.155428

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

静脉导管与周围神经再生

  

  • 收稿日期:2015-03-24 出版日期:2015-04-22 发布日期:2015-04-22

Peripheral nerve regeneration with conduits: use of vein tubes

Rodrigo Guerra Sabongi 1, Marcela Fernandes 2, João Baptista Gomes dos Santos 2   

  1. 1 Department of Orthopedics and Traumatology, Escola Paulista de Medicina, Federal University of São Paulo, Sa?o Paulo, Brazil
    2 Division of Hand Surgery, Department of Orthopedics and Traumatology, Escola Paulista de Medicina, Federal University of São Paulo,
    Sa?o Paulo, Brazil
  • Received:2015-03-24 Online:2015-04-22 Published:2015-04-22
  • Contact: Rodrigo Guerra Sabongi, M.D.,rsabongi@gmail.com.

摘要:

由于神经再生过程的复杂性,周围神经损伤的治疗仍是现代医学中具有挑战的一项课题。如何开发一种替代自体神经的移植物修复节段性神经缺损,并规避受体处的不良反应,如神经瘤的形成,疤痕和功能永久丧失,是临床研究的重点。现有合成的神经导管虽然可以方便快捷的修复神经损伤,但同时它增加了手术费用及异体排斥的风险。未来导管的研究应不仅能够支持轴突生长,而且能提高管腔内雪旺细胞的迁移,并提供生长促进因子促进神经再生。

Abstract:

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

Key words: peripheral nerve injury, nerve graft, nerve conduit, Wallerian degeneration, neurotrophic factors, veins, autografts, nerve regeneration