中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (5): 748-752.doi: 10.4103/1673-5374.156969

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

蛛网膜下腔出血脑血流动力学研究:如何改善预后的保护措施?

  

  • 收稿日期:2015-03-11 出版日期:2015-05-15 发布日期:2015-05-15

Encephalic hemodynamic phases in subarachnoid hemorrhage: how to improve the protective effect in patient prognoses

Marcelo de Lima Oliveira, Daniel Silva de Azevedo, Milena Krajnyk de Azevedo, Ricardo de Carvalho Nogueira, Manoel Jacobsen Teixeira, Edson Bor-Seng-Shu   

  1. Division of Neurological Surgery, Hospital das Clinicas, School of Medicine, University of São Paulo, São Paulo, Brazil
  • Received:2015-03-11 Online:2015-05-15 Published:2015-05-15
  • Contact: Marcelo de Lima Oliveira, Ph.D., marcelodtc@terra.com.br

摘要:

在蛛网膜下腔出血期间可出现不同的血液动力学模式:血量减少、充血和血管痉挛,每个模式都与大脑代谢变化有关。发生在初始24小时内的脑血流减少可能与强烈血量减少代谢危象有关;临界流量减少可以导致非血量减少代谢危象,包括线粒体功能障碍。超脑血量减少和非血量减少代谢危象可能与乳酸大量堆积和超急性期血流减少后的充血有关。血管痉挛阶段也与两种代谢危象相关联。

Abstract:

Subarachnoid hemorrhage is frequently associated with poor prognoses. Three different hemodynamic phases were identified during subarachnoid hemorrhage: oligemia, hyperemia, and vasospasm. Each phase is associated with brain metabolic changes. In this review, we correlated the hemodynamic phases with brain metabolism and potential treatment options in the hopes of improving patient prognoses.

Key words: hemodynamic phases, cerebral subarachnoid hemorrhage, metabolic crises