中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (6): 862-865.doi: 10.4103/1673-5374.158330

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

噬菌体靶向药物递送纳米载体可突破血脑屏障的限制

  

  • 收稿日期:2015-04-28 出版日期:2015-06-18 发布日期:2015-06-18

Phage display: development of nanocarriers for targeted drug delivery to the brain

Babak Bakhshinejad 1, Marzieh Karimi 1, Mohammad Khalaj-Kondori 2   

  1. 1 Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
    2 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  • Received:2015-04-28 Online:2015-06-18 Published:2015-06-18
  • Contact: Mohammad Khalaj-Kondori, Ph.D., khalaj@tabrizu.ac.ir.

摘要:

噬菌体是一种能感染细菌并劫持宿主细胞进行自我复制和遗传信息扩增的病毒。噬菌体在配体识别上展示出的巨大容量,可以获得理想的部分对纳米载体的表面进行官能化。从噬菌体展示库衍生肽创造的血脑屏障交叉脑靶向给药平台发展的新机遇。

Abstract:

The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be screened for finding brain targeting peptide ligands. Surface functionalization of a variety of nanocarriers with these brain homing peptides is a sophisticated way to develop nanobiotechnology-based drug delivery platforms that are able to cross the blood brain barrier. These efficient drug delivery systems raise our hopes for the diagnosis and treatment of various brain disorders in the future.

Key words: blood brain barrier, phage display, peptide library, nanocarrier, targeting