中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (6): 866-869.doi: 10.4103/1673-5374.158332

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

胞外基质蛋白-2:用于神经、肌肉和其它组织再生的一种胞外接头蛋白

  

  • 收稿日期:2015-04-17 出版日期:2015-06-18 发布日期:2015-06-18

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

Éva Korpos 1, 2, Ferenc Deák 3, 4, Ibolya Kiss 3, 4   

  1. 1 Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, 48149 Muenster, Germany
    2 Cells-in-Motion Cluster of Excellence, University of Muenster, 48149 Muenster, Germany
    3 Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, H-6701 Szeged, Hungary
    4 Avidin Ltd., H-6726 Szeged, Hungary
  • Received:2015-04-17 Online:2015-06-18 Published:2015-06-18
  • Contact: Ibolya Kiss, Ph.D., D.Sc., kiss@brc.hu.

摘要:

细胞外基质在发育和再生过程中对组织的分化、维持和重塑起到基本功能作用。细胞外基质的数量,成分,组织和功能显示,组织之间存在很大变数并且在细胞外基质相互作用过程中随之而来的改造会发生动态变化。

Abstract:

The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 (Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Matn2 can also promote or suppress tumor growth.