中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (8): 1191-1194.doi: 10.4103/1673-5374.162678

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

生物功能化纳米支架用于修复损伤周围神经的前景

  

  • 收稿日期:2015-06-13 出版日期:2015-08-24 发布日期:2015-08-24

Nanotechnology and bio-functionalisation for peripheral nerve regeneration

Tina Sedaghati1, Alexander M. Seifalian1, 2, 3   

  1. 1 Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK
    2 Royal Free NHS Trust Foundation Hospital, London, UK
    3 NanoRegMed Ltd, London, UK
  • Received:2015-06-13 Online:2015-08-24 Published:2015-08-24
  • Contact: Alexander M. Seifalian, Ph.D., a.seifalian@gmail.com.

摘要:

现在有一种新型智能生物材料,可以激发神经细胞的增殖,迁移并增强细胞物质的相互作用,促进跨越这些关键距离缺陷的神经再生,具有很高的临床需求。本文简要回顾了几种最新的,有前途的基于POSS纳米颗粒和纳米纤维支架的RGD肽序列,纳米复合材料可通过影响细胞行为,如附件,扩散和增殖提高周围神经再生能力与效果。本文的目标是要建立有效的操作,使其简单并易于在神经再生和修复的临床情况下使用。

Abstract:

There is a high clinical demand for new smart biomaterials, which stimulate neuronal cell proliferation, migration and increase cell-material interaction to facilitate nerve regeneration across these critical-sized defects. This article briefly reviews several up-to-date published studies using Arginine-Glycine-Aspartic acid peptide sequence, nanocomposite based on polyhedral oligomeric silsesquioxane nanoparticle and nanofibrous scaffolds as promising strategies to enhance peripheral nerve regeneration by influencing cellular behaviour such as attachment, spreading and proliferation. The aim is to establish the potent manipulations, which are simple and easy to employ in the clinical conditions for nerve regeneration and repair.

Key words: nanomaterial, regenerative medicine, biomaterial, peptides, nerve regeneration, stem cells, nanotechnology